Gastrointestinal Diseases Symptoms and Causes

Gastrointestinal diseases are diseases of  gastrointestinal tract. Gastrointestinal tract or digestive system tract is  system of serially connected organs from the mouth to the anus.

Mouth, Pharynx, esophagus, stomach, small intestine, large intestine, rectum and anus are major regions of digestive system.

Symptoms of gastrointestinal diseases are of various types. These  symptoms can occur in isolation or together.

Careful analysis of the clues provided both from the gut itself and from the effect of gut disease on the body as a whole are required if diagnosis is to be achieved.

There are some symptoms that occur during normal gut functioning and its awareness and cannot be considered as symptoms of gastrointestinal diseases.

For example, thirst and hunger are common symptoms. Hunger may be associated with epigastric discomfort or pain when intense.

Thirst can cause sensation of dryness of the mouth.

As we eat food the Swallowing is normally perceived, and there is temperature sensation in the upper and mid-oesophagus, as well as in the mouth. Normal gastric motility can, to some extent, be perceived and so could movement of gas and fluid in the gut, called borborygami.

Sensation of rectum and colon prior to defecation felt as call to stool, or during constipation is part of routine physiology and aspects of the normal sensation of gut activity.

But various diseases can cause these routine perceptions to alter and new symptoms may appear.

Various Symptoms of Gastrointestinal Diseases

Eructation or Belching

Eructation or belching [also known as burping, ructus, or eructation] is the release of gas from the digestive tract (mainly esophagus and stomach) through the mouth.

It is usually accompanied with a typical sound and, at times, an odor.

Belching is typically caused by expelling the air swallowed  when eating or drinking.

The sound of burping is caused by the vibration of the upper esophageal sphincter as the gas passes through it.

Belching is normally associated with regurgitation especially in lying position.

The valve at the top of the stomach does not produce a tight seal, and in the absence of gravity and the  stomach contents may  come up along with the expelled air.

Causes of Eructation

• Drinking  carbonated drinks such as beer, soft drinks, energy drinks
• Common diabetes drugs like  metformin
• Hiatus Hernia
• Food allergy
• Ulcer, acid reflux disease, H. pylori, and gastritis
• Gall bladder problems like cholecystitis
• Mouth breathing

Psychogenic causes like anxiety or depression

Dysphagia

Dysphagia is, the sensation of something sticking in the throat or chest during swallowing. It indicates a problem in  esophagus. Dysphagia could indicate esophageal stricture,  from benign or malignant causes. Dysphagia is a potentially serious symptom that should always be investigated.

Heartburn

Heart burn is the burning sensation due to acid reflex from the stomach into the lower part of the oesophagus. It causes pain in the epigastrium, chest and neck. It is difficult to distinguish from angina pectoris. Heartburn occurs usually at night when patient lies flat in bed, or after bending or stooping when abdominal pressure is increased.

List of causes of heart burn is

• Reflux esophagitis
• Hiatus hernia
• Peptic ulcer
• Faulty dietary habits
• Addictions
• Neurosis

Painful swallowing

This symptom is different from dysphagia and should not be confused with. Here, there is a pain on swallowing but the difficulty or sticking sensation is absent. It usually is due to local infection. It can occur in pharyingits. It is also occurs in patients with AIDS in whom candida or herpes simplex often occur in the esophagus.

Dysphagia

Dysphagia is difficulty in swallowing. It is a symptom and not a disease in itself. It is a pointer to some underlying disease. Following diseases/conditions can lead to dysphagia

• Esophagitis –  An inflammation in the esophagus
• Esophageal webs- Thin membranes of normal esophageal tissue consisting of mucosa and submucosa
• Esophageal Strictures
• Esophageal Tumors
• Achalasia Cardia- Failure of relaxation of lower esophageal sphincter
• Esophageal Spasm
• Hiatus Hernia
• Chagas’ disease (American trypanosomiasis)
• Scleroderma
• Radiation
• Pharyngeal & Laryngeal Lesions
• External compression
  • Cervical spondylitis
  • Retropharyngeal abscess
  • Goiter
  • Enlarged left atrium
  • Aaneurysm
• Neurological
  • Bulbar palsy
  • Polyneuropathy
  • Motor neuron disease
  • Myopathies
  • Myasthenia
  • Dermatomyositis.

Dyspepsia or Indigestion

This is actually group of symptoms which  include heartburn, pain, distension, nausea or ‘an acid feeling’ occurring after eating or drinking. The patients may also use this term to describe an inability to digest food. The symptom is subjective, frequent, and usually benign in origin. It sometimes may be associated  with peptic ulcer.

Cause of Indigestion could be any of the following

• Upper gastrointestinal tract
  • Alcohol
  • Heavy meals
  • Aerophagia
  • Hiatus hernia
  • Gastroesophageal reflux
  • Peptic ulcer disease
  • Gastritis
  • Drugs
• Lower gastrointestinal tract
  • Parasites
  • Food intolerance
  • Irritable bowel syndrome
  • Increased intraluminal gas
• Hepatobiliary
  • Cholecystitis
  • Stones
  • Pancreatitis
  • Splenic flexure syndrome
• Systemic diseases
  • Uremia,
  • Cardiac failure
  • Tuberculosis
  • Malignancy.
• Functional

Flatulence

It describes excessive wind. It is associated with belching, abdominal distension and the passage of flatus per rectum. It usually represents a functional disturbance in which excessive air is swallowed certain foods produce relatively large amount of gas, for example legumes, resulting in increased flatulence.  Very infrequently flatulence is associated with organic disease of the gastrointestinal tract.

Following are common causes of flatulence.

• Gastric Causes:
  • Aerophagy
  • Neurosis
  • Hiatus hernia
  • Pyloric stenosis
  • Biliary dyspepsia
  • Following vagotomy

• Food intake
  • Cabbage
  • Cauliflower
  • Peas
  • Beans
• Intestinal
  • Steatorrhea
  • Intestinal obstruction
  • Malignancy, etc.
• Systemic diseases
  • Cardiac failure
  • Cirrhosis

Hiccups

Hiccups are commonly occurring benign repeated sudden diaphragmatic contraction, often triggered by upper gastrointestinal irritation. They go on their own. Occasionally hiccups  indicate brainstem disease.

Nausea and Vomiting

Everyone once in a while has experienced both nausea and vomiting. Some people feel them more as compared to others. Vomiting is a neurogenic response trriggered by chemoreceptors in the brainstem or reflexly through irritation of the stomach. Vomiting consists of a phase of nausea, followed by hypersalivation, pallor, sweating and hyperventilation.

Retching is the term used for  an involuntary effort to vomit which is followed by expulsion of gastric content through nausea and vomiting of gastrointestinal origin is associated with local pain in the abdomen.

Following conditions may cause nausea and vomiting

• Abdominal Causes
  • Gastritis ulcer
  • Peptic ulcer
  • Colics
  • Acute abdominal emergencies
  • Appendicitis
  • Cholecystitis
  • Peritonitis
  • Pancreatitis
  • Intestinal obstruction
• Cardiac:
  • Myocardial infarction
  • Cardiac failure
• Central
  • Raised intracranial tension
  • Meningitis
  • Meniere’s disease
  • Motion sickness
  • Radiation
• Metabolic

• • • Diabetes
    • Alcohol Intake
    • Pregnancy
    • Hypercalcemia
    • Addison’s disease.
• Toxic
  • Febrile illnesses
  • Viral hepatitis
  • Drugs
  • Corrosive poisons.
• Functional

Constipation

Constipation is a subjective complaint. Patient gets a sense of inadequate emptying of  bowel by defecation. The term is sometimes used to describe the passage of hard stools, irrespective of stool frequency.

Constipation is most commonly used to indicate decrease in frequency of stools. The frequency of stool varies from person to person.  The passage of formed stool frequently than twice a week is usually taken to indicate an abnormality if bowel frequency in clinical practice.

Causes of Constipation can be summarized as below

Acute Constipation

• Intestinal obstruction
  • Volvulus-Abnormal twisting of the intestine causing obstruction
  • Intussusception- Infolding of one part of the intestine into another
  • Incarcerated Hernia
• Acute abdomen
  • Appendicitis
  • Salpingitis- Inflammation of Fallopian tubes
  • Perforation of gut
  • Colics or pain abdomen

Chronic Constipation

Constipation that is slow to develop and is present for long time.

• Faulty habits
  • Laxative abuse
  • Prolonged travel
  • Insufficient dietary roughage
• Painful anal conditions
  • Piles
  • Fissures
• Organic obstruction
  • Carcinoma
  • Diverticulum
  • Strictures
• Adynamic bowel
  • Scleroderma
  • Myopathies
  • Myotonia
• Metabolic:
  • Hypothyroidism
  • Hypokalemia
  • Hypercalcemia
  • Porphyria
  • Lead poisoning
• Drugs
  • Atropine and related drugs
  • Opium group
  • Tricyclic antidepressants

Diarrhoea

Diarrhoea consists of watery stools of large volume which may or may not contain blood. It indicates frequent loose motions. Usually diarrhoea occurs due to viral or bacterial infection.

Chronic diarrhoea should raise the possibility of malabsorption with steatorrhoea. Steatorrhoea is the passage of pale, bulky stools containing excessive fats that commonly float in water and are difficult to flush away.

Causes of diarrhoea can be summed up as

• Osmotic Causes
  • Laxative abuse
  • Maldigestion of food
• Infections
  • Typhoid
  • Cholera
  • Amebiasis
  • Giardiasis
  • Helminthiasis
• Endocrine diseases
  • Thyrotoxicosis
  • Diabetes
  • Addison’s disease
• Drugs
  • Thyroxine
  • Prostigmine
  • Ampicillin
  • Phenolphthalein
• Anxiety:
  • Irritable bowel syndrome
• Miscellaneous
  • Malignant carcinoid syndrome.

Abdominal Pain

Depending upon the causation the pain may occur in the upper abdomen, in the hypochondrium, in the lower abdomen, or in the rectum. The important features of abdominal pain are its site, intensity, character of duration and frequency. Aggravating and relieving factors should be noted.

Pain abdomen is very common complaint and symptom of many underlying diseases which could be

• Acid peptic disease
• Peritonitis
• Paralytic ileus
• Mechanical obstruction of hollow viscus
• Colics
  • Intestinal
  • Renal
  • Biliary
• Vascular disturbances causing ischemia
  • Thromboembolism
  • Sickle cell crisis
  • Rupture of aneurysm.
• Abdominal wall causes
  • Hernia through linea alba
  • Trauma
  • Infection
• Referred pain
  • Pneumonia
  • Pleurisy
  • Ischemic heart disease
  • panniculitis
  • Torsion of the testes or ovary
• Metabolic
  • Diabetes
  • Uremia
  • Porphyria
  • Lead poisoning
• Neurogenic
  • Herpes zoster
  • Tabes dorsalis
• Functional

Abdominal Distension

Abdominal distension has many causes. It may relate to flatulence, or more commonly to functional bowel disease in which the viscera are enlarged because their contractility is diminished from disease of the bowl musculature, or its innervation. Distension is also a feature of steatorrhoea [passage of fat laden stool], or from visceral enlargement in liver disease.

Weight Loss

Malabsorption of the food, loss of appetite or starvation are common causes of weight loss. It is also a feature of malignancy.

Hematemesis

Hematemesis is passage of blood in vomiting. It result from bleeding in the upper gastrointestinal tract.

Rectal Bleeding

It result from bleeding in the rectum or anal canal, most commonly from piles but sometimes from anal or rectal carcinoma. Hematoschezia is the term used for passage of fresh blood through anus. It indicates a pathology in lower gastrointestinal tract.

Melena refers to  passage of dark, partially digested blood along feces. It implies bleeding from a site more proximal than rectum, usually in the upper colon or small intestine.

Jaundice refers to yellowish appearance of skin and conjuctiva of eyes. It may be associated with other cutaneous systemic features of liver disease, often with dark urine.Jaundice is caused by increased bilirubin levels and implies disease of the liver or the biliary tract.

Jaundice could also result from excessive haemolysis.

These symptoms cover most of gastrointestinal diseases presentation.