VCAM1 gene is the gene responsible for encoding Vascular Cell Adhesion Molecule 1 which as the name suggests functions as a cell adhesion molecule VACM is a cell surface sialoglycoprotein, a type I membrane protein that is a member of the Ig superfamily.
The VCAM-1 gene is expressed on both large and small blood vessels only after the endothelial cells are stimulated by cytokines. It contains six or seven immunoglobulin domains, It is alternatively spliced to encode different isoforms in humans.
The VCAM-1 protein is responsible for mediation of the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium.
It also functions in leukocyte-endothelial cell signal transduction and is thought to play a role in atherosclerosis and rheumatoid arthritis development.
VCAM-1 is a potential target for developing drugs.« Back to Glossary Index