For the first time, researchers have decoded all the genes of a person with cancer and found a set of mutations that might have caused the disease or aided its progression.
Using cells donated by a woman in her 50s who died of leukemia, the scientist sequenced all the DNA from her cancer cells and compared it to the DNA from her own normal, healthy skin cells. Then they zeroed in on 10 mutations abnormal growth, preventing the ells from suppressing that growth and enabling them to fight off chemotherapy.
The findings will not help patients immediately, but researchers say they could lead to new therapies and would almost certainly help doctors make better choices among existing treatments, based on more detailed genetic picture of each patient’s cancer. Though the research involved leukemia, the same techniques can also be used to study other cancers.
“This is the first of many of these whole cancer genomes to be sequenced,” said Roichard Wilson, director of the Genome Sequening Center at Washington University in St Louis and the senior author of the study. “They’ll give us a whole bunch of clues about what’s going on in the DNA when cancer starts to bloom.”
The mutations-genetic mistakes found in this research were not inborn, but developed later in life, like most mutations that cause cancer. (Only 5 percent to 10 percent of all cancers are thought to be hereditary). The new research, by looking at the entire genome-all the DNA and aiming to find all the mutations involved in a particular cancer, differs markedly from earlier studies, which have searched fewer genes.
Wilson said he hoped that in 5 to 20 years, decoding a patient’s cancer genome would consist of dropping a spot of blood onto a chip that slides into a PC and getting a report suggesting which drugs will work best.
Source: TOI
