Research finds around 1000 molecular reactions to exercise, opening the door for drug treatments to mirror the health benefits of exercise.
Soon, we may be able to build the drugs that mimic the benefits of exercise, enabling the persons to reap benefits of exercise without exercising. This breakthrough has been suggested by research in University of Sydney’s Charles Perkins Centre.
The study has been published in journal Cell Metabolism.
The researchers have been able to expose a thousand molecular changes that occur in our muscles when we exercise, thus providing a comprehensive exercise blueprint, first of its kind in the world.
Exercise in a Bottle?
Exercise is the most powerful therapy for many human diseases, including type 2 diabetes, cardiovascular disease and neurological disorders. Exercise is prescribed as routine in these and other ailments. But for many people, exercise is not a viable option which could be due to variety of reasons. Therefore, we need to find ways of developing drugs that could provide benefits of exercise.
The researchers from the University of Sydney and University of Copenhagen in Denmark conducted this study by analyzing human skeletal muscle biopsies from four untrained, healthy males following 10 minutes of high intensity exercise.
They used mass spectrometry to study protein phosphorylation and discovered that short, intensive exercise triggers more than 1000 changes.
The study suggests that for any drug to provide benefit of exercise, we will need to target multiple molecules and pathways
Exercise produces plays an essential role in controlling energy metabolism and insulin sensitivity and the effect of exercise on muscles is quite complex.
Exercise causes a complicated series of changes to human muscle and it has been claimed to be first study to map the exact happening.
This could allow scientists to use this information to design a drug that mimics the true beneficial changes caused by exercise, researchers said.
The message is clear. The drug would need to target multiple points.
When it becomes reality, it would be just like exercise in a bottle.
Nolan J. Hoffman, Benjamin L. Parker, Rima Chaudhuri, Kelsey H. Fisher-Wellman, Maximilian Kleinert, Sean J. Humphrey, Pengyi Yang, Mira Holliday, Sophie Trefely, Daniel J. Fazakerley, Jacqueline Stöckli, James G. Burchfield, Thomas E. Jensen, Raja Jothi, Bente Kiens, Jørgen F.p. Wojtaszewski, Erik A. Richter, David E. James. Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. Cell Metabolism, 2015 DOI: 10.1016/j.cmet.2015.09.001