Massive Splenomegaly:
1. Malaria, kala azar
2. Chronic myeloid leukemia
3. Extrahepatic portal hypertension
4. Myelofibrosis
Moderate Splenomegaly:
1. All the above as in I
2. Hodgkin’s disease, leukemias, lymphomas, polycythemia rubra vera
3. Hemolytic anemias
4. Biliary cirrhosis
5. Hemochromatosis
6. Tumours and cysts
7. Tuberculosis
Mild Splenomegaly:
1. All the above as in I and II
2. Acute infections: Typhoid, septicemia, SBE
Acute Splenomegaly:
1. Acute infectious fevers: Typhoid, malaria, SBE
2. Injury: Hematoma, ruptured spleen
3. Vascular causes: Splenic infarct, thrombosis of splenic vein
4. Connective tissue disorders: SLE, rheumatoid arthritis, Felty’s and Still’s disease
5. Tumours and cysts
Hepatosplenomegaly:
1. Infective: Malaria, kala azar, infective hepatitis, SBE
2. Hematological conditions: Leukemia, lymphomas, Hodgkin’s disease, chronic hemolytic anemias
3. Congestive: CCF, pericarditis, Budd-Chiari’s syndrome and portal hypertension
4. Storage disorders: Glycogen storage, Amyloidosis
Hepatosplenomegaly with Lymphadenopathy:
1. Acute Leukemia
2. Hodgkin’s and Non-Hodgkin’s Lymphomas
3. Infectious mononucleosis
4. Disseminated Tuberculosis
5. Sarcoidosis
Splenomegaly with Pallor and Icterus:
1. Hemolytic anemia
2. Cirrhosis of liver with portal hypertension
Splenomegaly with Petechiae and Ecchymosis:
1. Acute Leukemia, blast crisis in CML and CLL stage IV
2. SBE
3. SLE
