Side Effects of Drugs During Treatment of Tuberculosis

Posted by MCT Team on Saturday, September 26, 2009 · Leave a Comment 

Isoniazid

Common side effects: Hepatitis, peripheral neuropathy
Uncommon side effects: Cutaneous reactions, arthralgia, drug induced lupus, optic neuritis, convulsions, mental symptoms aplastic anaemia, haemolytic anaemia agranulocytosis, gynaecomastia.

Rifampicin

Common side effects: Anorexia, nausea, vomiting, epigastric pain, hepatitis
Uncommon side effects: Anaemia, cutaneous reaction, flue like syndrome, shortness of breath, acute renal failure, shock, thrombocytopaenic purpura, haemolytic anaemia.

Pyrazinamide

Common side effects: Arthralgia (21 percent cases) hepatitis, anorexia, nausea, vomiting.
Uncommon side effects: Cutaneous reaction, hyperuricemia, sideroblastic anaemia.

Ethambutol

Common side effects: Retrobulbar neuritis, arthralga
Uncommon side effects: Cutaneous reactions, peripheral neuropathy.

Streptomycin

Common side effects: Cutaneous reactions, auditory and vestibular toxicity resulting in giddiness, numbness and tinnitus.
Uncommon side effects: Vertigo, ataxia and deafness-if streptomycin is continued despite early symptoms

Stop immediately and don’t reuse in case following reactions occur

  • Rifampicin – Acute haemolytic anaemia, shock, acute renal failure or thrombocytopaenic purpura.
  • Ethambutol – Retrobulbar neuritis.
  • Streptomycin – Deafness or ataxia.
  • Thiacetazone – Severe skin rashes or agranulocytosis.

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