Testosterone Therapy Improves Functional Capacity in Heart Failure Patients

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A recent metanalysis has shown that testosterone supplements in patients with heart failure improved the breathing and exercise.

The study which analyzed four randomized clinical trials of patients with moderate to severe heart failure, has been published in Circulation: Heart Failure

According to authors, low testosterone is an independent predictor of reduced exercise capacity and poor clinical outcomes in patients with heart failure  and they undertook the study to determine if testosterone therapy improves exercise capacity in patients with stable chronic HF. [Read more...]

Risk Factors For Stroke Also Predict Cognitive Decline

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A new study published in  November 8 issue of Neurology shows that known risk factors for stroke, such as high blood pressure and diabetes also increase  increase the risk for incident cognitive impairment. this holds true even for those who have never had a stroke.

The authors have stressed upon the importance of early intervention to treat high blood pressure to preserve cognitive health.

It appears that the total Stroke Risk Profile score, is also useful in determining the risk of cognitive problems. [Read more...]

Surgical Measures In Skin

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Surgical measures are an important component of dermatologic therapy, and should be adopted for lesions or diseases where medicinal therapy is ineffective or if the patient desires a quick result which cannot be achieved by medicinal treatment.

The lesions/diseases which require surgical procedures include:

  1. Benign lesions such as warts, molluscum contagiosum, corns, granuloma pyogenicum, melanocytic, vascular or epidermal naevi, adenoma sebaceum, trichoepithelioma, syringoma, cysts, milia and xanthelasma, [Read more...]

Cavernous Haemangioma In Vascular Nevi

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cavernous-haemangiomaIt is constituted by much larger vascular spaces which are lined by a single layer of endothelial cells. The lesions are usually present at birth and do not show any significant increase in size later. Clinically, they consist of red or bluish red irregular, lobulated masses which may be situated on any part of the body.

Surface lesions may manifest as reddish or bluish vesicles when situated near the eye or on the tongue, they may cause pressure symptoms and interfere with the function of the part. When situated on the pressure points such as the knee or the elbow, they may get easily traumatized and result in profuse bleeding. [Read more...]

Syndromes Associated With Hemangioma

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Osler-Weber-Rendu disease

This is also called hereditary haemorrhagic telangiectasia, which is characterized by multiple small aneurismal telangiectases distributed over the skin and mucous membrane of the body. These often present from birth and hereditary in origin which is transmitted by dominant Mendelian trait.

Twenty percent of cases lack family history.

Lesions are found beneath the skin in any region of the body or directly beneath the mucous membrane of the oral cavity, alimentary tract, respiratory tract and urinary tract and even in the brain, liver and spleen.

Individual lesions are smaller than 5 mm in diameter, but often coalesce to produce lesions upto several centimeters in diameter which are reddish blue in colour.

This case presents with haemorrhage from rupture of these lesions either into the intestinal tract, urinary or respiratory tract, nose bleeding etc.

It is relatively a rare condition.

Sturge-Weber syndrome

It is characterized by facial port-wine stain angioma alog with ipsilateral venous angiomas in the leptomeninges over the cerebral hemisphere.

It is often associated with mental retardation and attacks of Jacksonian epilepsy.

Capillary Hemangioma

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Capillary Haemangioma

Capillary Hemangioma [image credit:wikimedia]Four varieties of capillary haemangioma are seen

  • Salmon patch
  • Port-Wine stain
  • Strawberry angioma
  • Vin Rose patch.

Spider naevus, a type earlier included in capillary hemangioma actually arises from skin arteriole and not a true capillary haemangioma.

Salmon Patch

  • This is present since birth
  • It usually disappears before the first birthday
  • It is mostly seen over the middle of the forehead, or occiput or anywhere in the midline.

Port-Wine Stain

  • It is usually present since birth and does not show any change for the rest of the life. The size gradually varies in proportion to the whole body.
  • Common on the face, at the shoulders, neck and buttock.
  • This is deep purple-red in colour which may become paler in later life.
  • It is a diffuse vascular deformity. It may become nodular in some areas.
  • With pressure the colour diminishes in intensity, but when the pressure is released the colour of the naevus takes time to reappear as the feeding vessels are also abnormal.

Strawberry Angioma

  • Red mark is noticed after 1 to 3 weeks of birth that gradually increases in size comparatively rapidly for a few weeks or months till it takes a typical strawberry or raspberry-like swelling.
  • After the first birthday the angioma gradually regresses in size and may disappear by the age of 7 to 8 years.
  • The subcutaneous tissue as well as the skin is often involved. Sometimes muscles may be affected. Very rarely submucous strawberry angioma has been seen when it is prone to alarming haemorrhage.
  • The lesion is composed of immature vascular tissue.
  • This angioma is usually 1 to 2 cm in diameter, but this may become as large as upto 8 cm in diameter. Strawberry angioma is soft, compressible and not pulsatile. Sustained pressure will squeeze most of the blood out of the haemangioma leaving it collapsed. As soon as the pressure is released refilling occurs quickly. It is usually seen in the skin and is freely mobile with the skin.

Vin Rose Patch

It is a congenital intradermal vascular abnormality in which there is mild dilatation of vessels in the skin. This lesion takes a pale pink colour.

It may be associated with other vascular abnormalities e.g. extensive haemangiomata, arterio-venous fistula in the limb leading to giant limb lymphoedema etc.

This lesion can occur anywhere in the body. It does not cause any symptom. It is not dark enough to produce disfigurement. It is often accepted as minor birthmark and is of the forgotten about.

Treatment of Capillary Hemangioma

Majority of the capillary haemangiomas disappear on their own. So it is worthwhile to wait and watch.

If the lesion exists even after 8 years and the patient and the parents insist on treatment for cosmetic reason, the following are the treatment options available

  • Excision of the lesion with skin grafting.
  • Carbondioxide snow application.
  • Injection of hot water or hypertonic saline or sclerosing agent
  • X-ray therapy has not proved very successful, yet may be considered in failure cases though it may cause disturbances of growth, necrosis of skin, pigmentation and ulceration.
  • Injection of steroid.

CO2 or ND Yag Laser is now the treatment of choice when this expertise is available. This treatment is particularly useful in port-wine stain.

An Introduction To Haemangioma

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Capillary Hemangioma [image credit:wikimedia]
Capillary Hemangioma [image credit:wikimedia]

Haemangioma is a developmental malformation of blood vessels and not a typical tumour.  Haemangioma is often present since birth and  it never turns malignant.

Types of haemangioma-

There are mainly three types of haemangioma

  1. Capillary haemangioma – arising from capillaries.
  2. Venous or cavernous haemangioma – arising from the veins.
  3. Arterial or plexiform haemangioma – arising from arteries.

Haemangioma may occur anywhere in the body though it is more common in the skin and subcutaneous tissues.