Bipolar disorder is a category of mood disorders defined by the presence of one or more episodes of abnormally elevated energy levels, cognition, and mood with or without one or more episodes of depression.

It has been found that mood stabilizers approved for treating bipolar disorder decrease expression of markers of the brain arachidonic metabolic cascade when give to rats over a period of time.

Moreover they also reduce excitotoxicity and neuroinflammation-induced upregulation of these markers suggesting  that arachidonic acid cascade markers are upregulated in the brain with bipolar disorder. [Read more...]