Non Steroidal Anti-inflammatory Drugs May Cause Worsening Of Pneumonia

A recent article published in Chest has reported that use of Non steroidal antiinflammatory drugs may cause an alteration inn presentation and course of pneumonia.

The article is published in journal Chest in February issue and the authors in order are Guillaume Voiriot, Sandra Dury, Antoine Parrot, Charles Mayaud and Muriel Fartoukh

Nonsteroidal antiinflammatory drugs are used very commonly for pain and fever. The authors wanted to investigate the potential influence of Nonsteroidal antiinflammatory drugs (NSAIDs) on the presentation and short-term outcomes of nonimmunocompromised inpatients with community-acquired pneumonia admitted to the intensive care unit.

The study included  90 patients with community acquired pneumonia admitted to the ICU or step-down unit of a university hospital during a 4-year period. All cases were evaluated prospectively except when they were on long term non steroidal antiinflammatory drugs or steroids .

36% were found to have been administered NSAIDs before they were referred to hospital. This group of patients were younger and had fewer comorbidities as compared to the group who were not given any NSAIDs.  [Read more...]

Osseocartilaginous Rib Graft Rhinoplasty A Stable, Predictable Technique for Major Dorsal Reconstruction

In a new study published in Archives Of Facial Plastic Surgery, the data suggests that  osseocartilaginous dorsal onlay rib grafts used for augmentation rhinoplasty is a stable and predictable technique for dorsal reconstruction.

In this study,  58 rib graft rhinoplasties were performed in the 10-year review period, 39 of which used dorsal onlay grafts. The patient were followed for 24 months and the  median duration of clinical follow-up was 16 months.

Osseocartilaginous onlay grafts showed 100%  viability at the last follow up. In contrast only 83% cartilaginous onlay grafts were viable, rigid, and had maintained dorsal projection at last follow-up.

None of the grafts warped.

The relief of nasal obstruction was almost same. It was 88% in osseocartilaginous flaps and 83% in cartilaginous onlay grafts had persisting relief of their nasal obstruction. [Read more...]

Raised Testosterone in Umbilical Cord Blood Not Associated With Higher Risk for Infantile Hypertrophic Pyloric Stenosis In Male Infants:Study

A new report published in Pediatrics has  failed to find any association between high levels of testosterone and risk of infantile hypertrophic pyloric stenosis.

The risk of infantile hypertrophk pylonc stenosis is approximately 5 times more common in male than female infants. It has been hypothesized that the higher risk among male infants is associated with high levels of testosterone causing hypertrophy of the pylorus muscle. [Read more...]

Adalimumab Effective for Treatment of Chronic Plaque Psoriasis of the Hands and Feet

Adalimumab is a TNF inhibitor. A new randomized, placebo-Controlled, double-blind trial published in Archives of Dermatology online December 20, 2010 has suggested that adlaimumab is safe and effective for moderate to severe chronic plaque psoriasis involving hands and/or feet.

The study was  conducted by Craig Leonardi and colleagues and was a multicenter outpatient study in the United States and Canada.

All patients with chronic plaque psoriasis on the hands and/or feet with severity of f “moderate” or above were included in the study. [Read more...]

Corticosteroids Inhalation Slows Pulmonary Function Decline in Cystic Fibrosis

A recent publication in European Respiratory Journal has reported that inhaled corticosteroids  can slow the deterioration of  lung function in young children with cystic fibrosis.

The present study was led by Dr. De Boeck and colleagues who evaluated the effect of inhalational corticosteroids use on the evolution of lung function, growth, and insulin use in a retrospective analysis of data obtained from the Belgian Cystic Fibrosis Registry for the years 1998 to 2007. .

Eur Respir J. Posted November 11, 2010. Abstract

New Evidence Of Stem Cells Curing HIV Infection

In what has been considered as a medical breakthrough, the researchers from Germany have reported that a strong evidence has been found that HIV has been cured in a patient who received stem cell transplantation.

Read it here.

Evidence Of HIV Cure By Stem Cell Transplantation

In Elderly Women High Heart Function Could Be A Bad Thing

A new report published in American Heart Journal say that higher-than-normal ejection fraction can increase her risk of death after acute coronary syndromes.

The authors evaluated  5000 women (age >65 yrs) hospitalized for that indication, those with low left ventricular ejection fraction had the worst outcomes.

However,  2.8% of women with a high left ventricular ejection fraction above 65% also died in the hospital, compared to 1.8% of the group with normal ejection fraction.

Potential factors mentioned for higher ejection fraction in these patients are anemia, hypotension, increased sympathetic tone, and low stroke volume.

Am Heart J.  Posted November 2010. Abstract

American Congress of Obstetricians and Gynecologists Issues Guidelines on Care for HIV-Infected Women

The American College of Obstetricians and Gynecologists has found that  that women with HIV/AIDS are living longer, healthier lives and their need for routine gynecologic care is increasing.

In a practice bulletin issued in famous “Green Journal”, with the purpose of educating clinicians about routine HIV screening practices as well as basic women’s health screening and care, family planning, and preconception care for women who are infected with HIV. [Read more...]

Older Patients With Stroke Perform Better With Intravenous Thrombolytic Therapy: New Study

A new analysis has shown that patients older than 80 years with acute ischemic stroke perform better when treated with intravenous thrombolytic therapy than when left untreated.

It further stresses that the older patients would derive similar benefits from thrombolytic therapy as younger patients and are not at significantly greater risk for intracranial bleeding. [Read more...]

Very Low Birth Weight Infants With Down Syndrome Are At Greater Risk Of Heart And Lung Disease

Very-low-birth-weight infants with Down’s syndrome (DS) are at a greater risk for heart and lung disorders. This is suggested by a new study published online in Pediatrics.[ November 22]

The study was carried out with a goal to compare the rates of survival and neonatal morbidity for very low birth weight infants with down syndrome, very low birth weight infants with non Down’s syndrome chromosomal anomalies, nonchromosomal birth defects, and no chromosomal anomaly or major birth defect. [Read more...]