Adolescents Should Have Routine HIV Testing – American Academy of Pediatrics

Pediatricians should offer routine HIV testing to adolescent and young adult patients, American Academy of Pediatrics recommends in academy’s new policy statement published November print issue of Pediatrics.

It says

In light of the increasing numbers of people with HIV/AIDS and missed opportunities for HIV testing, the Centers for Disease Control and Prevention…recommends universal and routine HIV screening rather than targeted testing.

[Read more...]

A Small Trial Shows Gantenerumab Effective In Reducing Brain Amyloid in Alzheimer’s Disease

Treatment with gantenerumab, an anti–amyloid-β monoclonal antibody, results in a dose-dependent reduction in brain amyloid in patients with mild to moderate Alzheimer’s disease, a small trial shows.

However the study found no  effects on cognitive measures and doubts whether any reduction in brain amyloid level will translate into clinical efficacy.

Findings  were reported online October 10 in the Archives of Neurology. [Read more...]

Premature Birth Is A High Risk For Epilepsy Even In Adulthood

Prematurely born babies have a very high risk for epilepsy, not only at age 5 or 6, but as young adults in their 20s and 30s. the fact has been pointed by a recent cohort  study from Sweden led by Casey Crump, MD.

The study found that people who were born very preterm [23 to 31 weeks of gestation] had a 5-fold increased risk for epilepsy at the ages of 25 to 37 years when compared those  who were born full-term.

The study has been published in the October issue of Neurology. [Read more...]

Frequent Use of Aspirin Associated With Early Aging Macula Disorder

Frequent use of aspirin is associated with early and late aging macula disorder (AMD). The risks for those problems appear to be linked to how often aspirin is consumed.

A study of nearly 4691 European patients aged 65 years or older  published online September 13 in Ophthalmology has published these findings.

Dr. de Jong and colleagues conducted a cross-sectional, population-based study using structured interviews to assess aspirin use and AMD in 4691 people living in 7 European countries – Norway, Estonia, United Kingdom, France, Italy, Greece, and Spain. [Read more...]

Fluid Balance, Water Depletion and Water Intoxication

There are are two sources of fluid in our body

  • Exogenous – What we ingest
  • Endogenous Water released from oxidation of ingested food

Water is lost from the body by following routes

  •  Lungs – About 400 ml of water is lost in expired air each 24 hours [More in . In a dry atmosphere and with higher respiration rate]
  • Skin – By perspiration is always occurring. Varies with the atmospheric temperature and humidity, muscular activity and body temperature. Average loss is between 600 and 1000 m per 24 hours.
  • Faeces. Between 60 and 150 ml per day, increases in diarrohea.
  • Urine – In a healthy adult,the normal urinary output is approximately 1500 mlin 24 hours [Minimum required to o excrete the end products of protein metabolism - 400 ml in 24 hours]

[Read more...]

Clinical Photograph of Varicose Veins

Varicose veins are veins that have become enlarged and tortuous.

The term commonly refers to the veins on the leg.

 

Varicose Veins

Varicose Veins In Left Leg

Varicose Veins in the above photograph were seen in a 56 years old male who visited the OPD for some other ailment.

Chronic Hemarthrosis In Hemophilia

Recurrent bleeding episodes in a joint can lead to chronic changes in the joint occur. These changes affect all of the tissues within and surrounding the joint: synovium and cartilage, capsule and ligaments, bone and muscles.

Chronic synovitis is usually seen in the first and second decades of life and the management of chronic hemophilic arthropathy depends on the stage at which it is seen.

Following stages are seen in hemarthroses in hemophilia. [Read more...]

Clinical Photograph of The Leg With Cellulitis

Following is the clinical photograph of the patient showing marked redness in the leg .

Marked Redness Of Left Leg Because of Cellulitis

The redness is an important sign of inflammation The patient had cellulitis and did not have any comorbidity.

The patient was treated with antibiotics and elevation of the limb.

Non Steroidal Anti-inflammatory Drugs May Cause Worsening Of Pneumonia

A recent article published in Chest has reported that use of Non steroidal antiinflammatory drugs may cause an alteration inn presentation and course of pneumonia.

The article is published in journal Chest in February issue and the authors in order are Guillaume Voiriot, Sandra Dury, Antoine Parrot, Charles Mayaud and Muriel Fartoukh

Nonsteroidal antiinflammatory drugs are used very commonly for pain and fever. The authors wanted to investigate the potential influence of Nonsteroidal antiinflammatory drugs (NSAIDs) on the presentation and short-term outcomes of nonimmunocompromised inpatients with community-acquired pneumonia admitted to the intensive care unit.

The study included  90 patients with community acquired pneumonia admitted to the ICU or step-down unit of a university hospital during a 4-year period. All cases were evaluated prospectively except when they were on long term non steroidal antiinflammatory drugs or steroids .

36% were found to have been administered NSAIDs before they were referred to hospital. This group of patients were younger and had fewer comorbidities as compared to the group who were not given any NSAIDs.  [Read more...]

Mitochondrial Dysfunction Linked To Autism Disorder

A study published in journal Molecular Psychiatry has reported that, mitochondrial dysfunction  is more common in children with autism and autism spectrum disorder.

In this study, evidence from published research was collated after performing comprehensive search. Eighteen publications representing a total of 112 children with autism spectrum disorder and mitochondrial dysfunction were identified.  There were two main objectives defined for the study

  • To identify features of mitochondrial dysfunction in the general population of children with autism spectrum disorder.
  • To identify characteristics of mitochondrial dysfunction in children with ASD and concomitant mitochondrial disease

Also included was the comparison of published literature of autism spectrum disorder children without mitochondrial dysfunction and, and non-autism spectrum disorder children with mitochondrial dysfunction . [Read more...]