Neutrophil granulocyte migrates from the blood vessel to the matrix for phagocytosis
Neutrophil granulocytes, generally referred to as neutrophils, are the most abundant type of white blood cells in mammals and form an essential part of the immune system. Neutrophils are important in phagocytosing and digesting foreign particles at sites of inflammation and antigen entry. Neutrophils kill and dissolve microbes by
- Release of enzymes and bactericidal products from their intracytoplasmic granules
- By generation of toxic oxygen radicals and hypohalous acids.
Clinical deficiency of leukocytes manifests as recurrent skin and soft tissue infections with pyogenic organism and sepsis.
eosinophils (acidophils), are white blood cells that are one of the immune system components responsible for combating infection and parasites. Eosinophils are active in immunity against parasites, especially helminths, Eosinophils are specialized leukocytes whose granules contain numerous toxic products, including major basic protein, eosinophil peroxidase, and eosinophil cationic protein.
These products are especially toxic to helminthes. Activated eosinophils also produce large quantities of leukotriene C4 (LTC4) and TGF-β that promote increased venular permeability and fibroblast-dependent fibrosis, respectively.
